Enhancing Drug Solubility and Stability: Many promising drug candidates are hindered by poor aqueous solubility, resulting in limited bioavailability. By converting crystalline drugs into their amorphous form, we elevate their free energy state—dramatically improving solubility. Our work leverages this principle to design polymer-based formulations that stabilize amorphous drugs, optimizing both stability and dissolution performance.

Stabilizing Therapeutic Proteins: Monoclonal antibodies (mAbs) and other protein therapeutics are reshaping modern medicine, yet their solution-phase instability poses formulation challenges. Freeze-drying offers a robust pathway to solid-state stabilization, with disaccharides playing a pivotal role in preserving protein conformation and bioactivity. Through a deep understanding of molecular mobility, we identify optimal excipients to develop stable, freeze-dried protein formulations grounded in the principles of amorphous science.